CORRELATION BETWEEN HOMOCYSTEINE AND LIPID LEVELS IN PATIENTS WITH ISCHEMIC HEART DISEASE

Objective: To determine the correlation between homocysteine and lipid profile inpatients with ischemic heart disease. Methodology: This cross-sectional study was conducted on patients ofischemic heart disease aged 25-60 years admitted in coronary care unit ofPunjab Institute of Cardiology Lahore after ethical committee approval from 1stNovember 2014 to 31st October 2014. Fasting venous blood samples wereobtained from the participants to measure the plasma homocysteine levels andlipid profile. The patients were also assessed for traditional risk factors such asage, sex, family history of CVD, hypertension, smoking, dyslipidemia andphysical activity. The data was analyzed through SPSS version 22. Coefficient ofcorrelation (r) was calculated to establish correlation between the variables. Results: Total 105 patients were included. The mean age of the study populationwas 44.7±8.59 years. Among 105 participants 79 (75.2%) were males. Thevalue of co efficient correlation (r) for total cholesterol and Homocysteine was0.189 (p=0.006), for triglycerides and homocysteine was 0.12 (p=0.082), andfor LDL-C and homocysteine was 0.295 (p=0.000) showing weak positivecorrelation among the variables. On the other hand, the value of coefficientcorrelation for homocysteine and HDL-C represent a moderate negativecorrelation between these variables. Conclusion: The study revealed that homocysteine has significant but weakcorrelation with Total C, Triglycerides, and LDL-C showing that in patients withhigh homocysteine level the level of these biomarkers is also found to be raisedand vice versa. On the other hand, homocysteine has moderately weekcorrelation with HDL-C i.e., in patients with high level of homocysteine, the levelHDL-C was found to be decreased. Key Words: Homocysteine, Lipid profile, Ischemic heart disease, Cardiovasculardiseases.