A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

DNA methyltransferase-1 (DNMT1) is involved in CpG methylation, and its stability is known to be regulated by lysine methylation. Now it has been shown that methylation of DNMT1 and AKT1 phosphorylation of DNMT1 are mutually exclusive and that antagonism between these modifications affects DNMT1 turnover.