Occurrence of malaria positive cases and their association with serum creatinine and blood urea in different age group

Background: Malaria is a protozoan disease transmitted by the bite of infected anopheles mosquitoes. Malaria is one of the most serious parasitic diseases of the world affecting 300-500 million people and causing over 1 million deaths each year. Malaria is caused by Plasmodium species in human. 90% of the death from malaria is caused by P. falciparum and vivax. Complicated malaria is associated with multi organ dysfunction. ARF can be the presence of oliguria and increased serum creatinine and blood urea. Objective: To confirm malaria positive case by peripheral blood smear.To determine association of malaria positive case with kidney function test. Materials and Methods: The study was conducted in the department of microbiology TMMC&RC Moradabad. The study group comprised of 149 malaria positive cases confirmed by PBS & Antigen card test with serum creatinine and blood urea test. The sample venous blood was collected aseptically from the subjects using 5mL disposable syringes. The blood sample was collected and 4mL was transferred into plain vial for the biochemical assays whereas the remaining 1mL was transferred into EDTA vial for malaria parasite tests.  Result: Out of 1317 suspected cases in which 149(11.31%) samples were positive for malaria in which 140(93.95%) were infected with P. vivax and 9(6.04) were with P. falciparum. Out of 140 cases of P. vivax, 59(39.59%) had got deranged KFT while out of 9 cases of P. falciparum patients 5(3.35%) had got deranged  KFT. Conclusion: It is concluded that kidney function abnormality accounts for 42.18% in malaria positive cases. Keywords: Renal dysfunction, Plasmodium falciparum and, Plasmodium vivax, Mortality.