Synthesis and SAR Evaluation of Oxadiazolopyrazines as Selective Haemophilus influenzae Antibacterial Agents.
2003
Abstract The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4- b ]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with α-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C -6 give rise to the greatest Haemophilus influenzae antibacterial activity.
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