Determination of first trimester specific reference interval of anti thyroid peroxidase antibody - Study from a tertiary care hospital of Pakistan

This study emphasizes the need of trimester specific reference interval of thyroid antibody while interpreting the results in pregnant women with a suspicion of sub-clinical autoimmune hypothyroidism. in this study we determine the first trimester specific reference interval of thyroid peroxidase antibody among clinically euthyroid pregnant women. we chosen the first trimester as early detection of autoimmune hypothyroidism during pregnancy is crucial to reduce the adverse pregnancy outcomes (miscarriages and preterm delivery), if treated appropriately.