Relation of cyclooxygenase and heme oxygenase-1 genetic polymorphisms with aspirin resistance

目的 探讨环氧化酶1(COX-1)、COX 2和血红素氧合酶1(HO-1)的基因多态性与阿司匹林抵抗(AR)的相关性.方法 选择431例老年汉族心脑血管病患者,持续服用(75～100mg)阿司匹林≥1个月,通过花生四烯酸诱导光比浊法联合二磷酸腺苷诱导光比浊法,筛查出AR患者(AR组)36例,阿司匹林半抵抗患者(semi-AR组)164例和阿司匹林不抵抗患者(non AR组)231例.并对COX 1 rs1888943、rs1330344、rs3842787、rs5787、rs5789和rs5794,COX-2 rs20417和rs5277,HO-1 rs2071746共9个单核苷酸多态性位点的相关性进行比较.结果 与non-AR组和semi-AR组比较,AR组COX-1 rs1330344(-1676A/G)突变的G等位基因增加了发病风险(OR=1.77,95％CI:1.07～2.92,P=0.02)和(OR=1.66,95％CI:0.99～2.77,P=0.05).HO-1 rs2071746(-413 A＞T)突变T等位基因同样增加了发病风险(OR=1.70,95％CI:1.02～2.79,P=0.04)和(OR=1.68,95％CI:1.00～2.80,P=0.05).结论 COX-1 rs1330344和HO-1 rs2071746与老年汉族人群AR相关,COX-1 rs1888943、rs3842787、rs5787、rs5789、rs5794和COX 2 rs20417、rs5277与AR不相关,在汉族人群中罕见出现.