The Optimal Cutoff Value of ApolipoproteinB/ApolipoproteinA-I Ratio for the Diagnosis of Metabolic Syndrome and Insulinresistance in the Population of Georgia

Studies have indicated that ApoB/ApoA-I ratio is significantly associated with MetS and IR. This study was designedto assess the optimal cutoff values of ApolipoproteinB/ApolipoproteinA-I (ApoB/ApoA-I) ratio for the diagnosis of metabolic syndrome  and insulin resistance (IR) in the population of Georgia. The subjects were 1522 Georgians of Caucasian origin aged 18-80 (653 women and 869 men) without diabetes mellitus. MetS was diagnosed using the updated ATP-III definition of the metabolic syndrome. Receiver operating characteristics (ROC) curve analysis was performed to calculate the cutoff values. ROC analysis showed that areas under the curve (AUCs) of ApoB/ApoA-I ratio for the detection of MetS were 0.786±0.025 (95%CI: 0.737-0.834) in women and 0.815±0.017 (95%CI: 0.782-0.847) in men. AUCs of ApoB/ApoA-I ratio for the diagnosis of IR were 0.887±0.019 (95%CI: 0.850-0.924) in women and 0.816±0.022 (95%CI: 0.773-0.860) in men. After adjustment for age, MetS components and low-density lipoprotein cholesterol, odds ratios according to the determined cutoff values of ApoB/ApoA-I ratio were: for MetS – 1.75 in women and 1.18 in men; for IR – 13.61 in women and 7.75 in men. Study showed that in the population of Georgia optimal cutoff values of ApoB/ApoA-I ratio for the detection of MetS were 0.74 in women and 0.82 in men; for the detection of IR these values were 0.82 in women and 0.98 in men.