Composite Contrast Approach forCellular MRI usingtheCombination ofGadolinium Chelates andIronOxideParticles

Therearegrowing interests ofmolecular and development ofmagnetic contrast agents (CA)that enable to cellular imaging. Recently anumber ofimaging modalities have augmentitsintrinsic contrast in bothclinical and beendeveloped foracquiring biological information. Magneticexperimental settings. Unlike PET,theMRIdoesnotrequire Resonance Imaging (MRI)isanexcellent method forobserving theradioactive tagging agents, thusallows therepeated brainfunction and bio/molecular information withnon- m invasive and in-vivo stateand forexcellent anatomicalmeasurements. Thustheuseofcontrast agentaddshighly resolution. Contrast agent gives plentiful ability toMR imagingresletiologica infoRmation toathe se antid ca throughsignal enhancement and functional detection. resolution obtained inMR images, leading toawidescope Gadolinium chelates andsuperparamagnetic ironoxide ofapplications ofMRInotonlyfordiagnostic radiology but particles (SPIOs) arewidely usedMR contrast agents that have alsotherapeutic medicine (3). different relaxation properties ofpositive andnegativeParticularly, therecent studyofmolecular andcellular contrasts respectively. We suggested amethod exhibiting both imaging hasledtoan increased interest inmagnetic contrast characteristics byusing twocontrast agents with nanoparticles ascell labeling markers. Mostofthestudy aqueous mixture. We performed MR imaging formeasuringwiththeseCAshasexploited paramagnetic complexes and therelaxation effects ofcomposite samples anddemonstratedsuperparamagnetic