Ligament-bone composite scaffold with biomimetic connecting interface and forming method thereof
2013
The invention relates to a ligament-bone composite scaffold with a biomimetic connecting interface and a forming method thereof. The forming method comprises the following steps: firstly simulating a natural ligament-bone interface structure and utilizing a rapid forming technology to manufacture a resin negative type of a bone scaffold model with a fiber connecting structure; pouring a bone scaffold material solution into the resin negative type, and performing freeze-drying and high-temperature sintering to manufacture a bone scaffold with an internal communication pipeline and the fiber connecting structure; then primarily connecting ligament fiber with the fiber connecting structure of the bone scaffold, and fixing a die used for manufacturing of a biomimetic interface with a ligament-bone scaffold formed by primary connection; pouring the ligament material composite solution with the bone scaffold material in various changes of concentration into the interface of the ligament and the bone scaffold as secondary connection; and performing freeze-drying and removing the die, so as to obtain the ligament-bone composite scaffold with the biomimetic interface. According to the invention, the transmission of nutrients and metabolites is facilitated, the connecting strength of the ligament-bone composite scaffold is improved, and the ingrowth of cells after implantation is facilitated.
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