Subchronic inhalation toxicity and reproductive assessment in rats of three chlorinated propenes

Croups of 15 male and 15 female Sprague‐Dawley rats were exposed to 1 of 3 chloropropene (2,3‐Di = DCP; 1,2,3‐Tri = TRCP; and 1,1,2,3‐Tetra ‐ TECP) vapors to provide information on repeated exposures and the potential for reproductive impairment by the most likely route of occupational exposure. Target exposure concentrations were 0, 1, 5, and 15 ppm, 6 hid, 5 d/wk for 13 wk. The following parameters were evaluated: pharmacotoxic signs, survival, body weights, hematology, clinical blood chemistry, urine analysis, gross and histopathology (over 40 tissues/rat), organ weights, and selected weight ratios. Signs of nasal irritation were noted in rats exposed to 15 ppm of either DCP or TRCP but not TECP. Small decreases in overall body weight were observed in female rats exposed to 15 ppm TCP. An increase (∼15%) in spleen weight, with no corresponding histopathological or clinical findings, was observed in 15 ppm DCP‐treated male rats. No other effects considered related to treatment were observed following ex...