The NanDeSyn Database for Nannochloropsis systems and synthetic biology.

2020 
The unicellular industrial oleaginous microalgae Nannochloropsis spp. are model organisms for microalgal systems and synthetic biology. To facilitate community-based annotation and mining of the rapidly accumulated functional genomics resources, we have initiated an international consortium and present a comprehensive, multi-omics resource database named Nannochloropsis Design and Synthesis (NanDeSyn; http://nandesyn.single-cell.cn). Via the Tripal toolkit, it featured user friendly interfaces hosting genomic resources with gene annotations, and transcriptomic and proteomic data for six Nannochloropsis species, including two updated genomes of N. oceanica IMET1 and N. salina CCMP 1776. Toolboxes for search, Blast, synteny view, enrichment analysis, metabolic pathway analysis, genome browser, etc. were also included. In addition, functional validation of genes was indicated based on phenotypes of mutants and relevant bibliography. Furthermore, epigenomic resources were also incorporated, especially for small RNA-Seq including miRNAs and circRNAs. Such comprehensive and integrated landscapes of Nannochloropsis genomics and epigenomics will promote and accelerate community efforts in systems and synthetic biology of these industrially important microalgae.
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