Measurement of renal function with 111In-DTPA in dogs

Abstract The renal clearances of 111 In-DTPA were measured and compared with those of 125 I-iothalamate in dogs using three methods: (a) constant infusion method, (b) single injection UV/P method, and (c) single injection slope method. The renal clearances of 111 In-DTPA were on the average 9% higher than those of 125 I-iothalamate. Its urinary excretion was approximately 50% at 1 hr and about 80% at 4 hr, and bilary excretion was negligible. Sequential scintophotography of the renal system in dogs revealed the flow of the tracer through the kidneys, and excretion into the ureter and bladder.