ADJUVANT USE OF RADIOACTIVE COLLOIDS IN THE TREATMENT OF CARCINOMA OF THE OVARY.

The definitive treatment for malignant lesions of the ovary is removal of the tumor by hysterectomy and bilateral salpingo-oophorectomy. The peritoneal surfaces are a major route of metastasis in ovarian carcinoma (6), and at operation release of malignant cells into the peritoneum by spill from a cystic tumor, the presence of malignant cells in peritoneal washings, and superficial excrescences of tumor on the surface of the ovary are signs that peritoneal spread has already taken place or is highly likely. Such situations have been considered indications for postoperative radiation therapy. Irradiation of the entire peritoneal cavity by conventional external means at cancerocidal dose levels is not possible in most patients, however, because of the large volume of tissue to be treated. The definitive treatment for malignant lesions of the ovary is removal of the tumor by hysterectomy and bilateral salpingo-oophorectomy. The peritoneal surfaces are a major route of metastasis in ovarian carcinoma (6), and...