Isoniazid Hepatotoxicity in Childhood

A case of isoniazid-associated hepatitis has been encountered in a pediatric patient. Only two previous such patients have been reported in the pediatric literature.1,2 Both of those children had more cutaneous manifestations than liver involvement. For this reason the following patient is presented. CASE REPORT V.R. is a black girl who was admitted to The Children9s Hospital at 12 years of age for evaluation of pericarditis. The tuberculin skin test (PPD-5 T.U.) was positive with 20 mm of induration. Further studies, including cultures of pericardial fluid, eventually failed to prove a tuberculous etiology for the pericarditis. However, antituberculous therapy for at least one year was considered desirable.