Tanshinone IIA novel derivative, preparation method and applications thereof

The invention discloses a tanshinone IIA novel derivative, a preparation method and applications thereof, wherein the molecular formula of the novel derivative is C18H20O4, the molecular weight is 300.14, the structural formula is defined in the specification, and the novel derivative can be applied in preparation of drugs for inhibition of gastric cancers, colon cancers, breast cancers, liver cancers, lung cancers and other tumors. According to the present invention, the prepared novel derivative can directly target HMGB1 and effectively inhibit the proliferation of various tumor cells, and does not significantly affect normal cells; and the preparation method is stable, simple and easy to perform, and the prepared compound has stable property and high purity.