Comparison of allogeneic and autologous bone marrow transplantation for treatment of acute lymphocytic leukemia in childhood.

Currently, chemoradiotherapy with bone marrow transplantation from an allogeneic HLA-matched sibling donor provides the best prospect to treat patients with leukemia who relapsed or who are at very high risk for relapse after primary induction therapy. However, it is only a minority of patients with acute leukemia who have a matched allogeneic marrow donor [1, 2]. In this report we compare the results of allogeneic and autologous marrow transplantation in patients with high-risk acute lymphoblastic leukemia (ALL).