Abstract 15096: The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction: Insights From the Action Registry-GWTG

Introduction: Our aim was to determine whether frailty, a common syndrome in older adults, was associated with increased bleeding risk in the setting of acute myocardial infarction (AMI). Methods: We examined frailty among AMI patients age ≥65 treated at 775 U.S. hospitals participating in ACTION Registry-GWTG from 1/2015 - 12/2016. Frailty was classified based on impairments in 3 domains of functioning: walking (unassisted, assisted, non-ambulatory), cognition (normal, mildly impaired, moderately/severely impaired), and activities of daily living (ADLs; independent, partial assist ≥1 ADL, full assist ≥1 ADL). A summary frailty score was generated based on number of domains with none (0), mild (1) or full (2) impairments summed and grouped as (0, 1-2, 3-6). In-hospital major bleeding was defined using previous ACTION-GWTG Registry criteria. Multivariable logistic regression was used to examine the independent association between frailty and bleeding. Results: Among 129,330 AMI patients, 16.5% had any frai...