Value of interleukin-6, procalcitonin and C-reactive protein in early diagnosis of neonatal sepsis.

OBJECTIVE To study the value of interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)in early diagnosis of neonatal sepsis.METHODS IL-6 was determined by ELISA,PCT was determined by ILMA and CRP was determined by nephelometry.RESULTS The levels of IL-6,PCT and CRP in septic acute stage group were(283.54±61.72)ng/L,(13.87±8.54)μg/L and(19.73±9.14)mg/L.Their levels in septic restoration stage group were(61.50±13.69)ng/L,(0.89±0.33)μg/L and(3.35±2.16)mg/L,and their levels in control group were(57.14±10.88)ng/L,(0.77±0.21)μg/L and(2.82±1.83)mg/L.The levels of IL-6,PCT and CRP in septic acute stage group were significantly higher than those in restoration stage and in control group(P0.01).CONCLUSIONS IL-6,PCT and CRP can be used as rapid diagnostic markers for neonatal sepsis.Combining these tests together would raise the positive rate.