Phosphocitrate as an Inhibitor of Calcium Oxalate Crystallization in Vivo

1994 
Phosphocitrate (PC) is a naturally occurring inhibitor of calcification and has been demonstrated to be a potent inhibitor of hydroxyapatite (HAP) crystal growth and the transformation of amorphous calcium phosphate to HAP. It has also been shown to affect the crystallization of struvite and newberyite. However its impact on calcium oxalate (CaOx) crystallization is not well documented. We studied the effect of PC on CaOx crystallization in vivo in a rat model where crystallization is induced by low level hyperoxaluria in the presence of proximal tubular epithelial injury, since PC has also been demonstrated to provide protection against crystal-induced damage to the cell membranes.
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