Effects of ambient temperature and precipitation on the risk of dengue fever: A systematic review and updated meta-analysis.

Abstract Objectives We systematically reviewed the published studies on the relationship between dengue fever and meteorological factors and applied a meta-analysis to explore the effects of ambient temperature and precipitation on dengue fever. Methods We completed the literature search by the end of September 1st, 2019 using databases including Science Direct, PubMed, Web of Science, and Google Scholar. We extracted relative risks (RRs) in selected studies and converted all effect estimates to the RRs per 1 °C increase in temperature and 10 mm increase in precipitation, and combined all standardized RRs together using random-effect meta-analysis. Results Our results show that dengue fever was significantly associated with both temperature and precipitation. Our subgroup analyses suggested that the effect of temperature on dengue fever was most pronounced in high-income subtropical areas. The pooled RR of dengue fever associated with the maximum temperature was much lower than the overall effect. Conclusions Temperature and precipitation are important risk factors for dengue fever. Future studies should focus on factors that can distort the effects of temperature and precipitation.