MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS

Abstract Background:  Burn are trauma that can cause local and systemic damage including hypermetabolism, inflammation, and hyperglicemia. Stress Induced Hyperglycemia (SIH) occurs by increasing gluconeogenesis and insulin resistance. Both of these are mediated through an increase in regulated stress hormones and proinflammatory cytokines. Melatonin has been proposed as a burn supportive therapy that may prevent oxidative damage and inhibit excessive inflammatory responses. Aim:  Proving the effects of melatonin supplementation on blood glucose level in male Wistar rats with burn injury. Methods:  This research was an experimental with randomized control group pre-post test design. Twelve healthy male Wistar rats were included and divided into two groups, control and experimental group. Each rat was induced 30% burn injury under anesthesia. Rats in control group were given placebo, while rats in experimental group were treated with melatonin i.p at 0, 8 and 16 hours after burn injury. Blood samples were collected from the retroorbital sinuses at 0, 3, and 24 hours. Data were analyzed statistically by Paired t-Test and Independent t-Test.  Results:  In male Wistar rats with third degree burns given placebo, blood sugar levels significantly increase in 0-3 hours (p=0.006)  and 0-24 hours (p=0.037). Meanwhile, in male Wistar rats with third degree burns given melatonin, blood sugar levels did not change significantly in 0-3 hours (p=0.470), 0-24 hours (p=0.286), dan 3-24 hours (p=0.833).  Conclusions:  Melatonin administration can not significantly reduce blood sugar levels. Keywords:  Burn, burn injury, blood glucose level, melatonin.