Penitrem A and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance

Penitrem A is a mycotoxin mainly produced by Penicillium crustosum, a fungal species occurring in all climate zones, ranging from tropical to arctic areas. P. crustosum produces a wide range of toxic metabolites, including penitrems, thomitrems and roquefortine C. The major metabolite, penitrem A, has been associated with several episodes of mycotoxicosis in dogs. The clinical symptoms of acute penitrem A intoxication include classical signs of neurotoxicity, such as tremors, convulsions, ataxia and nystagmus. The outcomes of penitrem A intoxication in animals range from total recovery to death, depending mainly on the level of exposure. Cases of suspected human mycotoxicosis following exposure to P. crustosum infected food, beer or inhalation of dust have also been reported. The toxicokinetics of penitrem A is scarcely studied. The toxin is rapidly absorbed, as demonstrated by the rapid onset of symptoms after exposure, but the absorption has not been quantified. Penitrem A is transported systemically af...