Acute Infection Induces a Metastatic Niche: A Double Menace for Cancer Patients

Tumor-derived factors can induce a pre-metastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in cancer patients. New findings reveal increased metastasis to lung after acute bacterial infection via the CXCR4/Ubiquitin axis, suggesting new targets for anti-metastasis therapeutics.