Antibodies against beta amyloid glycosylation in the variable region.
2006
Composition comprising an antibody molecule that can specifically recognize -β-A4 / Aβ4 peptide, said antibody molecule of mono-glycosylated antibody molecule or double-glycosylated antibody molecule or wherein said composition comprises a mixture of said molecule Mono- antibody and said molecule double-glycosylated antibody, - wherein said molecule Mono- antibody comprises an asparagine (Asn) glycosylated at position 52 of SEQ ID NO: 2 or SEQ ID NO: 6 in the variable region the heavy chain (VH) and wherein said molecule double-glycosylated antibody comprises an asparagine (Asn) glycosylated at position 52 of SEQ ID NO: 2 or SEQ ID NO: 6 in the variable region of the heavy chain (VH) of both antibody binding sites, - wherein said antibody molecule comprises a CDR1 in the variable heavy chain as shown in SEQ ID NO: 10, CDR2 in the variable heavy chain as shown in SEQ ID NO: 12, a CDR3 in the variable heavy chain as shown in SEQ ID NO: 14, a CDR1 in the variable light chain as shown in SEQ ID NO: 16, a CDR2 in the variable light chain as shown in SEQ ID NO: 18 and a CDR3 in the variable light chain as shown in SEQ ID NO: 20, and wherein said composition comprises less than 5% of an antibody molecule characterized in that no binding site of said antigen antibody molecule comprises an asparagine (Asn) glycosylated in the variable region of the heavy chain (VH).
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