323 Chemotherapy Induced Diarrhea in Colorectal Cancer: A Retrospective Analysis of Clinico-Pathological and Radiological Features

number of goblet cells by endoscopic duodenum biopsies before and during chemotherapy. Degree of diarrhea was evaluated by NCI-CTC V4.0. Nutrition was evaluated by serum albumin and serum total protein before, during and after chemotherapy. Results:The mean DAO activities(± SD) in 20 patients were 4.88±2.06U/L before chemotherapy, 2.96±1.62U/ L during chemotherapy(day14) and 3.66±1.27U/L after drug holiday(day21). The DAO activity decreased significantly during chemotherapy and recovered significantly after drug holiday. Diarrhea(Grade1-3) appeared in 19 patients in the 10 to 18 day after administration of anticancer drugs and followed decrease in DAO activity. Villous height, villous surface area, the number of goblet cells were all significantly reduced by anticancer drugs and followed decrease in DAO activity. Serum albumin and serum total protein were significantly reduced by anticancer drugs and significantly increased after drug holiday. The DAO activity reduction rate between day1 and day14 was significantly correlated with albumin and total protein reduction rate between day1 and day21. Conclusion:Our results suggested that the DAO activity was useful as an indicative marker for intestinal mucosal damage, appearance of diarrhea and malnutrition in patients with chemotherapy.