Investigation of Antihypertensive activity of Leaves of Barleria Prionitis in Doca Salt Induced Hypertensive Rats

The present study was designed to determine the antihypertensive activity of methanolic extracts of leaves of barleria prionitis linn using DOCA salt induced antihypertensive model. The plant material was extracted using solvent methanol. Barleria prionitis L. (Family Acanthaceae; commonly known as Vajradanti), has a great potential against various disorders. For evaluation of this activity male albino wistar rats were uninephrectomized and randomly divided into five groups. Hypertension was induced by injecting DOCA-salt, 25 mg/kg BW subcutaneously, twice a week for six weeks, with NaCl 1% instead of tap water for drinking throughout the study. Systolic and diastolic Blood pressure was measured every week. B.prionitis showed significant anti hypertensive effect in DOCA salt induced hypertensive rats in dose of 200mg/b.w and 400mg/b.w.