Progress on nonhuman primate models of diabetes mellitus
2011
Diabetes is the third most severely chronic disease after
cardiovascular disease and cancer. World Health Organization (WHO)
estimated 220 million diabetes patients worldwide in 2009. The rational
animal models of diabetes are necessary for understanding the
mechanisms of diabetes, diagnosis and prevention of diabetes as well as
screen and evaluation of new drugs for diabetes treatment. Compared to
other animal models of diabetes, the causes and symptoms of diabetes of
nonhuman primates is more like human diabetes. We here reviewed the
reported nonhuman primate models of diabetes based on the sources they
were generated; especially focused on three models, Macaca mullata ,
M. fascicularis, Tupaia belangeri . Furthermore, we discussed the
perspective development of nonhuman primate models of diabetes
mellitus.
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