Rhabdomyolysis induced by co-administration of fluvastatin and colchicine Rabdomiolisi indotta da somministrazione contemporanea di fluvastatina e colchicina

Rhabdomyolysis induced by co-administration of fluvastatin and colchicine. F.M. Sarullo, L. Americo, A. Di Franco, P. Di Pasquale. A case of fluvastatin-induced rhabdomyolysis after co- administration of colchicine is reported. A 77 year old man with ischemic heart disease, chronic pericardial effusion, diabetes mellitus, dyslipidemia, arterial hypertension, chronic renal failure (stage 2 of classification of chronic kidney disease of National Kidney Foundation) and chronic gout presented with a generalized muscle pain. The patient had been taking 80 mg/day of fluvastatin for 4 years, and, for four weeks before presentation, he had also been taking a dose of colchicine (1.0 mg daily) for an exac- erbation of gout. Investigations confirmed the diagnosis of rhabdomyolysis. Discontinuation of fluvastatin and colchicine therapy and adequate fluid administration re- sulted in the resolution of clinical and biochemical features of rhabdomyolysis. Although neuromuscular adverse effects of fluvastatin and colchicine are well recognized, rhabdomyolysis is rare, making this is only the second case reported of fluvastatin and colchicine co-administration induced rhabdomyolysis in literature.