[A case of ovarian cancer in which a remarkable effect was seen with intrathoracic administration of CDDP and CPT-11].

: A-58-year-old female admitted to our hospital for abdominal fullness and dyspnea was diagnosed with malignant pleuro-peritonitis of advanced ovarian cancer. CT showed a massive right-sided pleural effusion, massive ascites, and large ovarian tumor (about 10 x 15 cm). The patient was treated with intrathoracic administration of CDDP and CPT-11. Combination chemotherapy of CDDP (10 mg/week) and CPT-11 (10 mg/week) was administered by intrapleural injection every other week. As a result (total amount; CDDP 310 mg, CPT-11 250 mg, in 9 months), pleural effusion and ascites disappeared. Moreover, marked shrinkage (about 3 x 4 cm) of the tumor was confirmed. This intrathoracic administration of CDDP and CPT-11 may be an effective loco-regional therapy for advanced ovarian cancer with malignant pleuro-peritonitis.