Multiple toxicity studies of trehalose in mice by intragastric administration

Abstract In the present study, aberration, body weight, food consumption, haematology, organ coefficients, and both gross and microscopic appearance of some histiocytes were compared between the test and control groups. A sperm abnormality test, bone marrow cell micronucleus test, and a haematology study were conducted at levels of 1.25 g/kg, 2.5 g/kg, and 5 g/kg of trehalose. In both the sperm abnormality test and bone marrow cell micronucleus test, statistically significant differences were observed between the positive control and treatment groups ( P  P  > 0.05). In the haematology study, there was no significant difference found from the controls at P  > 0.05. The results obtained in the present study could support the conclusion that consumption of trehalose has no adverse effects for humans.