Direct Relationship Between Uric Acid and C-Reactive Protein and Its Implication in the Chronic Kidney Disease

Chronic Kidney disease (CKD) is a serious life threatening disease associated with morbidity and mortality in India. Hypothetical relationship between serum uric acid and C-Reactive protein (CRP) levels has been demonstrated in the pathophysiology of CKD. Fifty chronic kidney disease patients before dialysis and fifty controls were executed for measurement of serum uric acid and C-Reactive protein as well as other biochemical parameters analysis. Serum C-Reactive protein was measured by quantitative turbidimetric immunoassay. In this study, serum uric acid, creatinine, urea and C-Reactive protein levels were significant raised in CKD group to that of controls. Notably serum C-Reactive protein levels were significantly higher in the CKD patients associated with non-diabetic factors in comparison to diabetic associated CKD patients. A receiver operating characteristic curve (ROC) exhibited a strong association between uric acid and C-Reactive protein levels. A strong direct relationship between serum uric acid and C-Reactive protein in CKD patients are plausibly culprits in the progression of diseases.