Experimental studies on the production of ethylalcohol habituation

Cholinesterase was determined by the biological method, using isolated Rectus abdominis of frog, in acute alcohol intoxicated and alcohol habituated rabbits. The results were as follows : The cholinesterase activity of brain, liver and serum of the acute intoxicated rabbits, showed approximately the same levels, when compared with the normal. rabbits. On the other hand, cholinesterase activity of tissues were significantly depressed in the alcohol habituated. It is probable that there is a certain relation between the acquirement of alcohol habituation and the depression of cholinesterase activity.