α, ω-Dodecanedioic acid production by Candida viswanathii ipe-1 with co-utilization of wheat straw hydrolysates and n-dodecane

Abstract Candida viswanathii ipe-1 was used to produce α , ω -dodecanedioic acid (DC 12 ), which showed capability to ferment xylose and glucose simultaneously, while arabinose utilization was less efficient. A low concentration of furfural enhanced cell growth, and the addition of 4.0 g/L sodium acetate largely increased DC 12 production. It indicated that detoxification of the wheat straw hydrolysates was not necessary for the biosynthesis of DC 12 . Based on the promising features of our strain, an efficient process was developed to produce DC 12 from co-utilization of wheat straw hydrolysates and n -dodecane. Using this process, 129.7 g/L DC 12 with a corresponding productivity of 1.13 g·L −1 ·h −1 could be produced, which was increased by 40.0% compared with a sole carbon of glucose. The improved DC 12 yield by the co-utilization of wheat straw hydrolysates and n -dodecane using C. viswanathii ipe-1 demonstrates the great potential of using biomass as a feedstock in the production of DC 12 .