Synthesis of HIV-1 Reverse Transcriptase Inhibitor DMP 266.
1998
Abstract Abstract: DMP 266, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor was prepared in six steps starting from commercially available 4-chlorophenyl isocyanate. The racemic compound was formed very efficiently from N-tert-butoxycarbonyl-4-chloroaniline and resolution was accomplished via the (-)-camphanates. Present address: B. I. Chemical, Inc., P.O. BOX 1658, Petersburg, VA 23805, U.S.A.)
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