Management of Melanoma Brain Metastasis

In the past decades, local therapies including surgery, whole-brain radiation therapy, and stereotactic radiosurgery were considered the pillar of metastatic brain metastasis (MBM) management, although their benefit in terms of overall survival was never demonstrated. Advances in understanding the biology and molecular pathways implicated in melanoma biology and consecutive improvements in metastatic melanoma treatment using anti-BRAF-based targeted therapies for BRAFV600-mutant melanoma as well as immune checkpoint immunotherapy have generated considerable interest in evaluating these novel systemic therapies in treating MBM (Table 22.1).