Association of the single nucleotide polymorphism TNRC9 rs3803662 on mammographic density and estrogen receptor-positive breast cancer risk in Japanese women.

1523 Background: The incidence of breast cancer in Japanese women has doubled in all age groups over the past two decades. We recently created risk prediction models for estrogen receptor (ER)-positive breast cancer in both pre- and post- menopausal women using genetic factors (single nucleotide polymorphisms (SNPs)), environmental risk factors, serum hormones and growth factors, by logistic regression analysis. However, mammographic density is also considered to be a risk factor for breast cancer. To acquire some insight into the relationships among SNPs, mammographic density and breast cancer risk, we analyzed the correlation between these factors. Methods: The study population comprised 913 consecutive Japanese women with breast cancer, and 278 control Japanese women. We analyzed the correlation between genetic factors (14 SNPs) and breast cancer risk in both premenopausal and postmenopausal women. We also analyzed differences in mammographic density between the SNP genotypes (homozygotes of major alle...