Methods of synthesis of benzazepines derivatives

A method for preparing {2-amino-8- [4- (pyrrolidinylcarbonyl) phenyl] - (3H-benzo [f] azepin-4-yl)} - N, N-dipropilcarboxamida comprising: (a) purifying a solution of (tert-butoxy) -N- {4- (N, N-dipropylcarbamoyl) -8- [4- (pyrrolidinylcarbonyl) phenyl] (3H-benzo [f] azepin-2-yl) carboxamide mixing the solution with sequestrant palladium; and (b) reacting (tert-butoxy) -N- {4- (N, N-dipropylcarbamoyl) -8- [4- (pyrrolidinylcarbonyl) phenyl] (3H-benzo [f] azepin-2- yl)} carboxamide a removing agent protecting group to provide {2-amino-8- [4- (pyrrolidinylcarbonyl) phenyl] - (3H-benzo [f] azepin-4-yl)} - N, N-dipropilcarboxamida, wherein palladium sequestrant is selected from: (i) silica beads functionalized with a functional group selected from - (CH2) 3-NH2, - (CH2) 3-SH and - (CH2) 3-NH- (CH2) 2- NH- (CH2) 2-NH2; (Ii) polystyrene beads functionalized -C6H4-CH2-NH2; and (iii) porous carbon particles having a surface area of ​​at least about 1200 m2 / g, an average pore diameter of about 1 nm and a particle diameter of about 0.3 mm to about 0.8 mm.