Kinetics for the Life Sciences: Some mathematical introductions

The origins of exponential behaviour Mathematics as the language for kinetics Some topics covered in this volume are more easily described by mathematical equations than by words, while others can only be described in algebraic language. An attempt is made in this chapter to state the mathematical principles which are the foundation of kinetic behaviour and to present the methods used to derive the equations which describe this behaviour. It is not essential to understand the contents of this chapter to benefit from the rest of this volume, but it is difficult to avoid mistakes in kinetic investigations without it. It will be seen that exponential curves of one sort or another crop up everywhere in the study of the rates of reactions. Not only is the change of concentration (or membrane current, etc.) frequently described by an exponential function of time (or by the sum of several such functions), but exponentials also appear in some of the more exotic ways of measuring rates, such as in the study of fluctuations and noise. Furthermore the study of individual molecules, as is possible for some sorts of ion channel, gives rise to probability distributions (e.g. the distribution of the length of time for which an individual channel stays open) that are also described by exponentials (Colquhoun & Hawkes, 1983). Unfortunately some of these topics can only be referred to in passing in the present volume. It is, however, important to realize that it is sometimes useful to distinguish between the lifetime of a state (or reaction intermediate) and the rate (or probability) of its decay.