GW27-e1123 Left cardiac sympathetic denervation with neuron targeted nanoparticles improves cardiac function and reduces ventricular arrhythmia inducibility in a canine post-infarction heart failure model

Left cardiac sympathetic denervation (LCSD) is an effective method to prevent post-infarction ventricular arrhythmia and sudden cardiac death. This study was to test the hypothesis that LCSD with tetanus toxin C fragment (TTC)-conjugated nanoparticles could attenuate cardiac dysfunction and