The Role of C-C Motif Chemokine Ligand 2 (CCL2) in Metastatic Neuroblastoma

Introduction: Approximately 80% of children with high-risk neuroblastoma experience remission after initial therapy, however the majority succumb to relapsed, incurable metastatic disease. The chemoattractant CCL2 has been found to promote metastasis in other cancers by recruiting tumor cells and monocytes to premetastatic sites. We sought to characterize the role of CCL2 in metastatic neuroblastoma. Methods: Metastatic human neuroblastoma (CHLA-255) cell …