Endocarditis of piglets associated with Staphylococcus aureus

To identify the pathogen causing endocarditis and splanchyic thrombosis of piglets and to observe the histopathologic changes in the internal organs of the affected animals,the bacteria isolated was identified by cultural properties,biochemical reactions,16S rDNA sequencing and 16S rDNA restriction analysis(ARDRA).In addition,pathogenicity and the drug-susceptibility of the pathogens isolated was determined by animal experiment and drug-sensitivity testing.It was found that the pathogen causing endocarditis in piglets was proved to be highly homologous Staphylococcus aureus which was hypersensitive to Aneet and Amikacin,but resistant to penicillin(S201).As demonstrated by animal experiment,the strain S201 and S202 showed stronger pathogenicity to experimental animals in which necrosis in heart,liver,spleen and lymph node of lower jaw and thrombosis and DIC in heart,liver,spleen,lungs and lymph nodes could be demonstrated by histological examinations and the pathological changes were most prominent in heart.It is evident that highly homologous S.aurus can cause endocarditis,splanchnic necrosis,thrombosis and DIC in piglets.