Research on heterocyclic compounds — Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity

Abstract The synthesis of a group of 2-methylimidazo[1,2- a ]pyrimidine-3-carboxylic esters, acids and amides is described. The structures of new compounds are supported by 1 H and 13 C NMR spectra. These compounds were tested in vivo for their antiinflammatory, analgesic and ulcerogenic activity. Eight new compounds out of fifteenshowed remarkable dose-dependent antiinflammatory action in the carrageenan rat paw edema (1/2–1/3 × indomethacin) but weak analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action. The new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro.