Combinations comprising a selective inhibitor of cyclooxygenase-2.

A combination comprising (a) a selective cyclooxygenase-2 inhibitor of formula (I) wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluorine; R3 is hydrogen, fluorine, chlorine, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluorine; and R5 is chloro, fluoro, trifluoromethyl or methyl; pharmaceutically acceptable salts or solvates thereof; and (b) an epothilone, in which the active ingredients (a) and (b) are present in each case in free form or in form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier, for simultaneous, separate or sequential.