Pharmacokinetics and tissue distribution of carboplatin liposomes after intravenous administration to mice

Purpose: To study the pharmacokinetics and tissues distribution of carboplatin liposomes after intravenous administration to mice in comparison with that of carboplatin injection. Methods: Carboplatin liposomes were prepared with L-α-phosphatidylcholine (PC), cholesterol (Chol), sterylglucoside (SG), and mannitol according to the lipid fi lm hydration method. The pharmacokinetics and tissue distribution of Pt in carboplatin were studied after intravenous administration of carboplatin liposomes with a particle size of 125 nm and following an injection of carboplatin into mice. The Pt concentrations were determined by atomic absorption spectrometry. Results: The concentration-time profi les of Pt following administration of both carboplatin liposomes and carboplatin injection fi tted a two-compartment model. In liver, spleen, and serum, the AUC0-∞ and mean residence time (MRT) of Pt following administration of carboplatin liposomes was much higher than that following a carboplatin injection (For AUC0-∞, in spleen and liver, P<0.01, and in serum, P<0.05; for MRT, in spleen and serum, P<0.01, and in liver, P<0.05). Conclusion: Carboplatin liposomes exhibit different pharmacokinetics and tissue distribution and may increase the therapeutic effi ciency in comparison with a carboplatin injection.