Pharmaceutical composition taking podophyllotoxin as main active component and preparation method of same

A pharmaceutical composition taking podophyllotoxin as a main active component consists of a chitosan-stearic acid graft and podophyllotoxin, wherein the podophyllotoxin is 5-20% of the total weight; and the amino substituting degree of the chitosan-stearic acid graft is 25-50%. Compared with the traditional anti-tumor medicine podophyllotoxin, the pharmaceutical composition taking podophyllotoxin as the main active component has better water solubility, can significantly improve an inhibitory effect on tumor cells, and provides possibility for being further developed into medicines for treating a variety of cancers.