THU0207 Influence by Orlistat Therapy Obesity on Clinical Symptoms of Knee Osteoarthritis in Women with Overweight

Background Osteoarthritis is an important social and medical problem. Obesity is an main modifiable risk factor for the development and progression of knee osteoarthritis. Objectives The aim of the study is to evaluate the influence of weight reduction on clinical symptoms and quality of life of patients with knee osteoarthritis. Methods The study included 50 women, aged 45-65 years with knee osteoarthritis stage II-III Kellgren-Lawrence and obesity (body mass index (BMI) >30kg/cm 2 ). Control group consisted of 23 women aged 48 to 65 years with knee osteoarthritis and BMI 2 . Obese patients were randomized into 2 groups. 1st group (25 patients) took orlistat a dose of 120 mg (1 tablet) 3 times daily for 6 months in combination with a low-calorie diet and physical activity. 2 group (25 patients) - non-pharmacological therapy of obesity (hypocaloric diet and physical activity). Patients in both groups received standard treatment regimen osteoarthritis. Functional index WOMAC, quality of life according to VAS were evaluated. Results Comparison of osteoarthritis patients with obesity (BMI>30kg/cm 2 ) and without (BMI 2 ) revealed that although patients with overweight were slightly younger (mean age 55,6±5,3 and 58,7±5,4 years) and had a shorter duration of the disease (7±3,7 years and 9,3±4,1 years, respectively), but they had more severe osteoarthritis: in obesity knee osteoarthritis stage III was more frequently detected (11.4% vs4,3%), a significantly higher index WOMAC (p Conclusions Our study demonstrated that weight loss, especially while taking drugs that reduce weight by obese patients with knee osteoarthritis leads to a reduction in the clinical developments of knee osteoarthritis: relieve pain and improve the functional state of the knee. In this connection, drugs that affect the weight loss should be included in the treatment regimen of patients with osteoarthritis and obesity. Disclosure of Interest : None declared DOI 10.1136/annrheumdis-2014-eular.2440