THE EFFECT OF A NON-ANDROGENIC TESTISEXTRACT ON THE ESTROUS CYCLE IN RATS

IT HAS BEEN DEMONSTRATED that one characteristic of the androgens is that of depression of the gonadotropic activity of the anterior lobe of the pituitary. This subject has been studied in this laboratory and reviewed by Cutuly and Cutuly (i). It is thought that it is because of this characteristic that androgens in adequatedosages will depress the estrogenic cycle in the female rat. It also has been known thatlipoid insoluble non androgenic extracts of the testes could be obtained which wouldcause atrophy of the secondary sex organs of the male rat. The most recent and moststriking demonstration of this effect is due to Vidgoff (2). The present publicationdeals with the effect of non androgenic testicular extracts on the estrous cycle of thefemale rat.