Synthesis and biological evaluation of aPtdIns(3,4,5)P3 affinity matrix

Gavin F. Painter,Jan W. Thuring,Ze-Yi Lim,Andrew B. Holmes,Phillip T. Hawkins,Leonard R. Stephens

Synthesis and biological evaluation of aPtdIns(3,4,5)P3 affinity matrix

2001

Gavin F. Painter
Jan W. Thuring
Ze-Yi Lim
Andrew B. Holmes
Phillip T. Hawkins
Leonard R. Stephens

New PtdIns(3,4,5)P3 binding proteins have been identified utilising PtdIns(3,4,5)P3 modified affinity matrix 1 which was synthesised from myo-inositol derivative 2, phosphoramidite 9 and an agarose based solid support.

Keywords:

Combinatorial chemistry
DNA-binding protein
Organic chemistry
Matrix (mathematics)
Agarose
Phosphoramidite
Chemistry
affinity matrix
biological evaluation

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