A Highly Enantioselective Synthesis of (R)-(-)-2-Acetyl-5,8-dimethoxy- 1,2,3,4-tetrahydro-2-naphthol. A Key Intermediate in the Synthesis of Anthracyclinones.
1991
Abstract AB-Synthon (R)-(−)- 5 , a key intermediate in the asymmetric synthesis of anthracyclinones 3 and 4 is prepared in 35% overall yield and > 95% ee. The key step involves hydroxylation of the potassium enolate of 7 using N-sulfonyloxaziridine (−)- 6c .
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