Полиморфизм генов синтеза и метаболизма эстрогенов и риск рака молочной железы

The genetic polymorphism of enzymes of synthesis and metabolism of estrogens can input into predisposition to breast cancer. The purpose of actual study was to analyze the associations of polymorphic loci CYP171B1rs10556836, CYP1A1rs1048943, CYP1A2rs762551, CYP19A1rs2470152 and CYP17A1rs743572 with risk of development of breast cancer in Russian residents of the Western-Siberian region of Russia. The rates of alleles and genotypes of the given loci were determined in sampling of women suffering with breast cancer (n=670 females) and in control group (480 females without oncological diseases). The sub-groups of patients with breast cancer in pre-menopause and postmenopause were analyzed separately. The border-line association of locus CYP17A1rs743572 is demonstrated with increasing of risk of breast cancer during pre-menopause (allele C: p=0.04). Among the rest of polymorphic loci no association was detected.